Articles of interest


Adherence, Safety, and Effectiveness of Medical Cannabis and Epidemiological Characteristics of the Patient Population: A Prospective Study
Medical cannabinoids: a pharmacology-based systematic review and meta-analysis for all relevant medical indications.
The Endocannabinoid System: A Potential Target for the Treatment of Various Diseases


A large Australian longitudinal cohort registry demonstrates sustained safety and efficacy of oral medicinal cannabis for at least two years
Epidemiological characteristics, safety and efficacy of medical cannabis in the elderly
Safety, Pharmacokinetics and Pharmacodynamics of Spectrum Yellow Oil in Healthy Participants
A Phase I, Randomized, Double-Blind, Placebo-Controlled, Single Ascending Dose, Multiple Dose, and Food Effect Trial of the Safety, Tolerability and Pharmacokinetics of Highly Purified Cannabidiol in Healthy Subjects

Palliative care

Experience With Medical Marijuana for Cancer Patients in the Palliative Setting
The Effectiveness and Safety of Medical Cannabis for Treating Cancer Related Symptoms in Oncology Patients
Perception of Benefits and Harms of Medical Cannabis among Seriously Ill Patients in an Outpatient Palliative Care Practice
Prospective analysis of safety and efficacy of medical cannabis in large unselected population of patients with cancer

Chronic pain

Efficacy of cannabis-based medications compared to placebo for the treatment of chronic neuropathic pain: a systematic review with meta-analysis
Cannabis and cannabinoids for the treatment of people with chronic noncancer pain conditions: a systematic review and meta-analysis of controlled and observational studies
Effectiveness and Tolerability of Dronabinol Use in Patients with Chronic Pain: A Retrospective Analysis of 12-Week Open-Label Real-World Data Provided by the German Pain e-Registry
Chronic Pain and the Endocannabinoid System: Smart Lipids – A Novel Therapeutic Option?


A phase 1b randomised, placebo-controlled trial of nabiximols cannabinoid oromucosal spray with temozolomide in patients with recurrent glioblastoma
Cannabidiol Μay Prolong Survival in Patients With Glioblastoma Multiforme
Prospective analysis of safety and efficacy of medical cannabis in large unselected population of patients with cancer
Report of objective clinical responses of cancer patients to pharmaceutical-grade synthetic cannabidiol
Towards the use of cannabinoids as antitumour agents
A pilot clinical study of Delta9-tetrahydrocannabinol in patients with recurrent glioblastoma multiforme

Sleep disorders

Medicinal cannabis improves sleep in adults with insomnia: a randomised double-blind placebo-controlled crossover study
Treating Insomnia Symptoms with Medicinal Cannabis: A Randomized, Cross-Over Trial of the Efficacy of a Cannabinoid Medicine Compared with Placebo
Cannabinoid therapies in the management of sleep disorders: A systematic review of preclinical and clinical studies
Cannabinoids, Endocannabinoids and Sleep


Clinical and cognitive improvement following full-spectrum, high-cannabidiol treatment for anxiety: open-label data from a two-stage, phase 2 clinical trial
An investigation of cannabis use for insomnia in depression and anxiety in a naturalistic sample
The endocannabinoid system in guarding against fear, anxiety and stress


Long-term efficacy and safety of cannabidiol in patients with treatment-resistant epilepsies: 4-year results from the expanded access program
Neuropediatrics Clinical Outcome Data of Children Treated with Cannabis Based Medicinal Products for Treatment Resistant Epilepsy – Analysis from the UK Medical Cannabis Registry
Use of cannabidiol in the treatment of epilepsy : Lennox-Gastaut syndrome , Dravet syndrome , and tuberous sclerosis complex
Cannabidiol Treatment for Refractory Epilepsies in Pediatrics

Inflammatory bowel disease

The effect of medical cannabis in inflammatory bowel disease: analysis from the UK Medical Cannabis Registry
Endocannabinoid System as a Promising Therapeutic Target in Inflammatory Bowel Disease – A Systematic Review
Irritable Bowel Syndrome: Manipulating the Endocannabinoid System as First-Line Treatment


Medical Cannabis for Gynecologic Pain Conditions: A Systematic Review
Role of the endocannabinoid system in the pathophysiology of endometriosis and therapeutic implications
Dysmenorrhoea: Can Medicinal Cannabis Bring New Hope for a Collective Group of Women Suffering in Pain, Globally?
Use of Cannabis for Self-Management of Chronic Pelvic Pain
Cannabis Use, a Self-Management Strategy Among Australian Women With Endometriosis: Results From a National Online Survey

Multiple sclerosis

Evidence-based management of multiple sclerosis spasticity with nabiximols oromucosal spray in clinical practice: a 10-year recap
Neurological Benefits , Clinical Challenges , and Neuropathologic Promise of Medical Marijuana : A Systematic Review of Cannabinoid Effects in Multiple Sclerosis and Experimental Models of Demyelination
Safety and efficacy of nabiximols on spasticity symptoms in patients with motor neuron disease (CANALS): a multicentre, double-blind, randomised, placebo-controlled, phase 2 trial

Huntington's disease

Cannabinoids for treatment of dystonia in huntington’s disease
A double-blind, randomized, cross-over, placebo-controlled, pilot trial with Sativex in Huntington’s disease
Cannabinoids and Huntington’s disease


Effects of Nabilone on Sleep Outcomes in Patients with Parkinson’s Disease: A Post-hoc Analysis of NMS-Nab Study
Non-Motor Symptoms in Parkinson’s Disease are Reduced by Nabilone
Evidence for the use of cannabinoids in Parkinson’s disease

Alzheimer / Dementia

Cannabinoids for behavioral symptoms in severe dementia: Safety and feasibility in a long-term pilot observational study in nineteen patients
Effects of rich cannabidiol oil on behavioral disturbances in patients with dementia : A placebo controlled randomized clinical trial
A Systematic Review of Clinical Studies on the Effect of Psychoactive Cannabinoids in Psychiatric Conditions in Alzheimer Dementia
Randomized Placebo-Controlled Trial of Nabilone for Agitation in Alzheimer’s Disease

Skin diseases

Cannabinoids for the Treatment of Dermatologic Conditions
Topical cannabidiol-based treatment for psoriasis: A dual-centre randomized placebo-controlled study
Cannabinoid signaling in the skin: Therapeutic potential of the «C(ut)annabinoid» system

Autism Spectrum Disorder

Clinical outcome analysis of patients with autism spectrum disorder: analysis from the UK Medical Cannabis Registry
Evaluation of the efficacy and safety of cannabidiol-rich cannabis extract in children with autism spectrum disorder: randomized, double-blind and controlled placebo clinical trial
Clinical Data on Canabinoids: Translational Research in the Treatment of Autism Spectrum Disorders


Assessment of clinical outcomes of medicinal cannabis therapy for depression : analysis from the UK Medical Cannabis Registry
An investigation of cannabis use for insomnia in depression and anxiety in a naturalistic sample
The effectiveness of cannabis flower for immediate relief from symptoms of depression

Tourette syndrome / Dystonia

A Double-Blind, Randomized, Controlled Crossover Trial of Cannabis in Adults with Tourette Syndrome
Cannabidiol as a promising strategy to treat and prevent movement disorders?
6-Week Trial of THC for Tics in Tourette Syndrome in the Treatment of Tics in Tourette Syndrome: a 6-Week Randomized Trial
Randomised, double-blind, placebo-controlled trial to assess the potential of cannabinoid receptor stimulation in the treatment of dystonia

Addiction / Drug dependency

Cannabidiol in the context of substance use disorder treatment: A systematic review
Opioid-sparing effect of cannabinoids for analgesia: an updated systematic review and meta-analysis of preclinical and clinical studies
Substitution of medical cannabis for pharmaceutical agents for pain, anxiety, and sleep
Role of Cannabidiol in the Therapeutic Intervention for Substance Use Disorders
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